DRMTLGY Medical Grade Skincare and a Natural Skincare Formulator’s Perspective on their Ingredients – Part 1 

In a world brimming with skincare brands, DRMTLGY has emerged as a noteworthy player, capturing the attention of skincare enthusiasts everywhere. With its promise of effective and science-backed formulas, DRMTLGY has gained significant popularity. This review takes a deep dive into the ingredients from a few of their most popular products and gives you my perspective based on my 12 years of experience formulating natural skincare products. 

DRMTLGY needle-less serum

DRMTLGY Needle-less Serum

DRMTLGY claims this as their top seller. This twice-a-day serum targets the appearance of fine lines around the mouth, eyes, and forehead while also hydrating the skin to give a radiant glow. This is a watery gel packed with ceramides, peptides, and hyaluronic acid. Its main active ingredients are Sodium Hyaluronate, everything that has peptide and ceremide in its label, panthenol, and a complex that stimulates the synthesis of collagen and elastin and reduce wrinkles. Panthenol and Sodium hyaluronic acid are the main ingredients in a "Hydrating B5 Gel". If your skin loves hydrating B5,  then you would most likely enjoy this product. I don't love the disodium EDTA, which is an ingredient used to sequester and decrease the activity of metal ions. However, it is a necessary ingredient for any product that is made with tap water instead of distilled is going to require this ingredient to keep the metal in the water from reacting with other ingredients. There are also thickeners and preservatives to round out a product that contains 80-90% water. 

The full ingredients are - 

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum (Pea) Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine HCl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum

Let's take a deep dive in to find the ACTIVE INGREDIENTS. 

Antioxidant: Pisum Sativum (Pea) Extract, Bambusa Vulgaris Leaf/Stem Extract

Cell-communicating ingredients: Methylglucoside Phosphate, Copper Lysinate/Prolinate, Niacinamide, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5

Skin brightening: Ceramide EOP, Ceramide NP, Ceramide AP

Skin identical ingredients: Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate

Sodium Hyaluronate

Commonly known as Hyaluronic Acid, it is one of the skin care industry's favorite "anti-aging" ingredients. When you see this ingredient in the formulation, expect a watery gel or a light cream that plumps and creates a dewy glow. This is because Sodium Hyaluronate is a humectant, and as such, not only does it prevent the loss of moisture, it attracts water from the environment and keeps it on your skin. HA is one of the best and super ingredients when it comes to its ability to attract and binding water. If you have dry skin, trying a product with this ingredient is a must. High concentrations of hyaluronic acid are better than low, but I am not able to determine the percentage used in this formulation. Based on the location of the ingredients, my guess would be between 5-10%. 

Sodium Chondroitin Sulfate

Similar to Sodium Hyaluronate, it is a substance that has good water-binding ability. It is not as good as HA due to its molecular size, but it works well with HA. 

Palmitoyl Tripeptides

A peptide that is backed by research for minimizing the appearance of wrinkles. This is a safe ingredient that has low concerns for cancer, developmental and reproductive toxicity. 


They are waxy lipids that can be found naturally in the outer layer of the skin (called stratum corneum - SC). The goopy stuff between our skin cells is called the extracellular matrix, which consists mainly of lipids. And ceramides are about 50% of those lipids (the other important ones are cholesterol at 25% and fatty acids at 15%). 

Methylglucoside Phosphate, Copper Lysinate/Prolinate

These are known as the skincare ingredient Neodermyl. It shows promising results in reducing deep wrinkles and improves skin firmness. 

DRMTLGY Product Range and Efficacy

DRMTLGY offers an extensive product range that effectively caters to a wide range of skin types and tones. The brand's dedication to inclusivity is evident through formulations that address the needs of individuals with dry, sensitive, and oily skin, among others.

Inclusive Formulations and Medical-Grade Skincare

DRMTLGY's commitment to inclusivity is evident in its formulations, ensuring that individuals with diverse skin tones can benefit from their products. The brand's medical-grade skincare offerings are formulated with potent ingredients at high concentrations, providing optimal efficacy. Users appreciate the brand's focus on clean and safe ingredients, avoiding harmful substances commonly found in skincare products. DRMTLGY's dedication to clinical testing and scientific research underscores its position as a medical-grade skin care brand.

User Experiences and New Product Offerings

Reviews from Organic Beauty Lover and Illuminate Labs highlight positive user experiences with DRMTLGY products. Users with various skin concerns, including fine lines, sensitive skin, and dark spots, have reported visible improvements after incorporating DRMTLGY into their skincare routines. The high concentration of hyaluronic acid in certain products enhances skin hydration and elasticity, contributing to a more youthful appearance.

DRMTLGY's commitment to continuous innovation is reflected in its introduction of new products that address emerging skincare needs. These additions demonstrate the brand's dedication to staying at the forefront of the skincare industry, providing effective solutions for a wide range of concerns.

One key ingredient in DRMTLGY's products is Vitamin E. Users appreciate the inclusion of this powerful antioxidant, which provides protection against skin damage caused by free radicals. Vitamin E-infused products, such as the Anti-Aging Serum and Needle-Less Serum, receive high praise for their ability to combat fine lines, improve skin texture, and promote a healthy, radiant glow.

Simple Rules and SPF-First Approach: DRMTLGY's commitment to simplicity and sun protection is reflected in its "SPF-first" approach. The brand emphasizes the importance of sun protection as a vital step in any skincare routine. This approach aligns with the recommendations of dermatologists, as harmful UV rays contribute to premature aging, dark spots, and skin damage.

DRMTLGY offers a range of best-in-class sunscreens, including mineral-based options with zinc oxide as the active ingredient. Users appreciate the absence of white cast often associated with mineral sunscreens, providing a seamless application experience. The brand's dedication to sun protection extends to blue light, with some products specifically formulated to shield the skin from the potential damage caused by electronic devices.

DRMTLGY stands out in the skincare industry as a brand committed to providing effective and inclusive skincare solutions. Its diverse product range caters to various skin types and tones, ensuring that individuals can find suitable options for their specific needs. The brand's science-backed formulations, emphasis on sun protection, and incorporation of active ingredients like Vitamin E have garnered positive reviews from users.

Love and light,


Mimi May